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Lynch DA, Sverzellati N, Travis WD, Brown KK, Colby TV, Galvin JR, et al

Cellular GSH level is maintained by a complex homeostatic mechanism, among which glutamate cysteine ligase (GCL), consisting of catalytic (GCLC) and regulatory (GCLM) subunits, plays major roles in GSH synthesis

*Correspondence: C (Linda) MC van Campen, [email protected] This article was submitted to Pharmaceutical Medicine and Outcomes Research, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Pushing doses up too fast is the single biggest cause of dropping out