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[ 21 ] Activated NF-B translocates to the nucleus to [ 22 ] facilitate the expression of pro-IL-1, IL-6, pro-IL-18, and of the different elements of the inflammasome: AIM2, NLRP3, apoptosis-associated speck containing a caspase recruitment domain (CARD) (ASC)-like protein, pro-caspase and pro-gasdermin D
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