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Nature 569, 723728

B-12 promotes normal growth and development of cells

A short trial of treatment with rhIGF-1 resulted in normalization of circulating IGF-I, suppression of GH hypersecretion and a markedly decreased insulin response to a meal tolerance test (91)

Common research dose 300-500 mcg/day in research planning context, drawn from the dose range used across the published Phase 1/2 trials
