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Description
The mechanistic rationale for adjunctive use is strong

K.CenasN.DickancaitE.Segura-AguilarJ

ROS are also known to modulate the activity of voltage-dependent Ca 2+ channels, the most affected being the activity of L-type Calcium channels

[DOI] [PubMed] [Google Scholar] [76].Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, et al

This stability is attributed to its unique amino acid composition, which includes multiple proline residues that create conformational constraints resistant to protease activity
