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Additionally, in vitro studies confirm that LMWF (Wu et al., 2021) alleviates EMT and fibrotic phenotype by simultaneously blocking TGF-/Smad and PI3K/Akt pathways in A549 cells, indicating multifaceted therapeutic effects

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S32, HSP90 was significantly upregulated in the ZFPG, ZFP + US, and ZFPG + US groups (increased by 10.27, 13.37, and 19.12 folds, respectively), ascribed to the ZFPG-mediated enhanced thermal damage and oxidative stress from US cavitation