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Treatment of the 3xTgAD Alzheimers disease model mice with ketone ester [(R)-3-hydroxybutyl-(R)-3-hydroxybutyrate], which is metabolized into two molecules of the ketone body beta-hydroxybutyrate, increased the cerebral cortical cytoplasmic [NAD + ]/[NADH] by 70% (from 230 to 390) and increased the hippocampal [NAD + ]/[NADH] by 65% (from 250 to 410), as inferred from the increased pyruvate/lactate (Pawlosky et al., 2017)

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

Different studies show that polyphenol produces antifibrotic and (MI) myocardial protective effects through regulating the oxidative stress, inflammation and fibrotic molecular signals

Cheng, Y., Zhong, C., Yan, S., Chen, C

coli K12 to form a separate clade (Fig