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Inflammatory responses and metabolic disorders in the tumor microenvironment suppress immune cell activity.The product inhibits NNMT, reduces inflammatory factor levels, improves the tumor microenvironment, promotes immune cell infiltration and activation, and thereby enhances the recognition and killing of tumor cells by immunotherapeutic agents, offering a new strategy for cancer immune combination therapy

This can be performed with the assistance of NO-system, given that in apomorphine or amphetamine (acute application) and methamphetamine (chronic application) rats, BPC 157 therapy counteracts the effects of NO-agents application [70]