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Meanwhile, systemic antitumor therapy has been reported with very limited success

In addition to MDA and 4-HNE, the most prominent markers of lipid peroxidation, such as isoprostanes, have been established as biomarkers and have received extensive attention

doi: 10.1016/j.cmet.2019.12.012

This is a genotype adapted to episodes of starvation that conserves energy and causes weight gain in a nutrition abundant modern world