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PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system

These symptoms, which can range from mild to severe, have been reported throughout the literature in both prospective and population-based studies in Lyme disease endemic regions

The association of oxidative stress and disease activity in seborrheic dermatitis