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Structure and biosynthesis of crocagins: polycyclic posttranslationally modified ribosomal peptides from Chondromyces crocatus

Inflammation can be acute and brought to timely resolution (homeostatic inflammation) or continue on to become chronic (pathogenic inflammation)

Prostaglandin E2 (PGE2) along with HER2 and growth factors enhance aromatase activity via post-transcriptional mechanisms in BrCa cells mediated by the IGF-1/IGF-1R axis through both AKT and MAPK pathways

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Some need both in a coordinated plan
