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Description
Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects
J Physiol 140, 381407 (1958)

This is usually related to your activity level, and more activity usually causes more swelling
And what you'll find is that epitalin is available as a synthetic compound

Brain & Nerve Protection Studied in preclinical models for neuroprotective effects and nerve injury recovery