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Selinexor inhibits XPO1 and has been approved for the treatment of patients with relapsed/refractory multiple myeloma after one to three prior lines of therapy in combination with bortezomib or pomalidomide with dexamethasone, or after 3 prior lines with dexamethasone alone

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The protein expression profile in the plasma revealed that edaravone treatment mainly reversed the expression of proteins related to oxidative stress, while edaravone prevention was more likely to modulate proteins related to immune responses