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In another study on PD patients and healthy controls based on NM-MRI, there was significant reduction in the lateral, central, and medial appearance of the NM high-intensity signals in the SN in patients with early PD (Wang et al., 2018)

doi: 10.1002/ptr.3293 60 PichicheroECicconiRMatteiMMuziMGCaniniA

Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis

There is a plateau in treatment effect which could be due to balance between the up regulation of melanogenesis in the hyperpigmented area and the downregulation by niacinamide
