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In a multicenter retrospective study of over 500 patients undergoing treatment with either IV or oral NAC or both for acetaminophen poisoning, NAC was associated with nausea and vomiting rates of 7.2 and 6.5%, respectively, in the IV group compared with 20 and 13.1% in the oral cohort [83]

The resolution of this debate likely hinges on technical advancements that allow direct, compartment-specific measurement of metabolic fluxes and oxygen dynamics in the tissue parenchyma

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