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The downregulation of OCTN2 activity and protein expression in the kidney reduces the reabsorption of carnitine in the kidney, leading to a decrease in carnitine availability in the liver and causing hepatic lipid metabolism disorders [260]
Recently, the ketogenic diet has been used in the treatment of various neurological diseases [39,40,41]
To evaluate potential alternative acetyl-CoA producing pathways, we generated cancer cell lines in which ACLY and ACSS2 are genetically deleted individually or in combination
