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Recent advances in activating silent biosynthetic gene clusters in bacteria
Orphanet J Rare Dis 19:415
O'Malley YQ, Reszka KJ, Spitz DR, Denning GM, Britigan BE.Pseudomonas aeruginosapyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells
The ,-unsaturated enone moiety of resorcylic acid lactones is susceptible to Michael addition reaction with a conserved cysteine residue (Cys166 in human ERK2) (95)
Here, we observed that labeled NAC predominantly increased the unlabeled-GSH pool, suggesting that NAC increased GSH via indirect pathways
