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After a closed head injury, ApoE / mice exhibit elevated levels of iron in their brains, suggesting that ApoE / deficiency may increase the risk of oxidative damage to hippocampal tissue ( In vitro studies show that upregulating sestrin2 decreases type I/II collagen and KEAP1 mRNA expression while increasing GPX4 and Nrf2 mRNA levels

Standard prenatal vitamins containing 2.5-10 micrograms may be insufficient for those with dietary deficiency, so dedicated B12 supplementation is recommended

Shivakumar G, Bernstein IH, Suppes T, Keck PE, McElroy SL, Altshuler LL, et al

Excess oxidative activity may reduce the availability of nitric oxide, a molecule that helps blood vessels relax
