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10.1016/j.bbagrm.2022.194814 83 ZhengL.FengL.JiangW

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Cham: Springer Nature Switzerland Giri A, Bharti VK, Angmo K, Kalia S, Kumar B (2016) Fluoride induced oxidative stress, immune system and apoptosis in animals: a review

Dysregulation of the de novo serine synthesis pathway impairs T-cell proliferation and their antitumor immune function ( + T-cell infiltration and is highly upregulated in breast cancer and papillary renal cell carcinoma ( In addition, activation of the serine synthesis pathway in glioblastoma attenuates the therapeutic efficacy of CAR-T cells, whereas PHGDH inhibition restores the antitumor activity of immune cells by enhancing STAT1 signaling ( Taken together, the de novo serine synthesis pathway (SSP) serves as a critical component of tumor metabolic reprogramming, driving malignant tumor progression through multi-dimensional regulatory mechanisms

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