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Crizotinib, a class Ia small molecule dual inhibitor of c-MET and anaplastic lymphoma kinase (ALK) had been proposed for advanced non-small cell lung cancer therapy with activation of either c-ros oncogene 1 (ROS-1) or ALK [110]
Being delivered directly into the bloodstream through a dense network of blood vessels in the oral soft tissues, the product is easily absorbed
Han et al., 2015)
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