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Encorafenib plus cetuximab with or without binimetinib for BRAFV600E metastatic colorectal cancer (mCRC): Relationship between carcinoembryonic antigen (CEA) and clinical outcomes from BEACON CRC

Although many of the VacA-mediated effects either directly or indirectly result from membrane binding and pore formation, VacA also enters the cytosol, subsequently accumulates in the mitochondrial inner membrane, and activates endogenous mitochondrial channels, thereby inducing apoptosis (105, 212, 329, 691)

doi: 10.3390/cells9051102 22 YoonTKLeeCHKwonOKimMS

doi:10.1089/ars.2013.5260 Sharma S, Black SM

Several environmental factors have been shown to induce oxidative stress on the ocular surface