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These findings underscore four core principles of chronotherapeutic MRIS management: Dawn BMAL1 activation upregulates hepatic CPT1A, driving peak FAO at sunrise, a rhythm exploited by administering CPT1A inhibitors at dawn to maximally suppress pathological lipid flux

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doi: 10.1002/jimd.12378

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Inclusion criteria selected for patients with a diagnosis of epilepsy, an average of at least 2 seizures per month over the preceding 3 months prior to starting MAD, at least 18 years of age at the time of enrollment, having baseline carnitine lab measurement prior to starting MAD, and at least one carnitine lab measurement at a follow-up timepoint