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5 random images were acquired by Nikon Eclipse Si microscope and EdU positive cells were quantified by ImageJ

As an indispensable trace element in the human body, the imbalance of iron homeostasis may lead to a variety of physiological disorders, including lung fibrotic disease (107)

The dense extracellular matrix (ECM) excessively secreted by PSC creates a physical hurdle that contributes to increased interstitial fluid pressure 10 , impaired hemoperfusion 11 , cellular hypoxia 12 , and blockage of nutrient and drug delivery 13

The ROS are the operating agents to create an oxidative state of the body

In probing the mechanisms of ferroptosis within the hepatic microenvironment, we question whether such mitochondrial anomalies are a driving force or simply a corollary of ferroptosis