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Perhaps LAC may be the next potentially effective and tolerable treatment with new mechanisms for patients with depression, especially for elderly and female patients, as well as patients with concomitant diseases who are vulnerable to the adverse effects of antidepressants

PARP, and PARP-1 in particular, uses NAD + to add ADP-ribose residues and target proteins to DNA (127129)

doi: 10.1016/j.cell.2008.06.016

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