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doi: 10.1016/j.jtho.2021.07.017

Dellovade TL, Young M, Ross EP, et al

To acquire energy, FA activation is a must, where FAs are converted into acyl-CoA by the acyl-CoA synthetase on the outer mitochondrial membrane, followed by entering mitochondria with the assistance of carnitine palmitoyltransferase 1 (CPT1) on the outer mitochondrial membrane together with carnitine-acylcarnitine translocase (CACT) and carnitine palmitoyltransferase 2 (CPT2) on the inner membrane [112]

Transcriptional responses to Cys depletion To gain insights into the molecular responses triggered by cysteine deprivation, we conducted bulk RNA-sequencing (RNA-seq) analysis of liver (which exhibits the highest expression of Cse ), muscle (the most abundant tissue) and adipose tissue (the tissue most impacted by cysteine loss)

With the progress of clinical trials such as KEYNOTE-426, the combined use of immune checkpoint and protein tyrosine kinase inhibitors is now one of the standard treatment options for most patients with metastatic RCC (150)