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This work was supported by the following grants: the New Quality Clinical Specialty Program of High-end Medical Disciplinary Construction in Shanghai Pudong New Area (Project No

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However, challenges such as poor bioavailability, model variability, and lack of clinical validation must be addressed through standardized protocols and long-term studies

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Mice with signs of unrelated illness, abnormal baseline renal function, or technical failure during surgery/crystal injection were excluded from analysis

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