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Although repurposing existing drugs offers a cost-effective and time-efficient alternative for identifying new therapies, their effective concentrationsmeasured as the half-maximal inhibitory concentration (IC50)often exceed the maximum safe plasma levels in humans, creating a major barrier to clinical application

Results SM-PNPs therapy demonstrated stronger hepatoprotective activity than unencapsulated SM

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FIGURE 6 The aforementioned results suggested that the GHK-derived peptides exerted their anti-oxidative, anti-aging, and wound-healing activities in skin cells
