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doi:10.1016/s0022-3476(88)80114-8

How it Works 5-Amino 1MQ works by interacting with a specific enzyme in the body called Nicotinamide N-methyltransferase (NNMT)

These large, fragile red blood cells pass into your bloodstream through your bone marrow and break down, causing excessive bilirubin

These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects