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[7] [8] NAD+ and NADH are continuously recycled during redox reactions, but during other metabolic activities, they are absorbed by NAD+-dependent enzymes and may subsequently become depleted over time, increasing the risk of DNA damage, age-related illnesses, and mitochondrial malfunction

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10.1073/pnas.1002459107 271 SyedN.LangerJ.JanczarK.SinghP.Lo NigroC.LattanzioL.et al