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There is also ample evidence to demonstrate that stimulation of the melanocortin pathway by inflammatory cytokines results in cachexia

doi: 10.1038/nm.2415 15 NgSWKMitchellAKennedyJAChenWCMcLeodJIbrahimovaNet al

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NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release
