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Nevertheless, the degree of downregulation is less pronounced compared to CTLA-4 (58), indicating that the equilibrium between CD28 and CTLA-4 plays a role in preserving the immune homeostasis of the orbit

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It may normalise DLPFC neurotransmission and mediate procognitive action by blocking the production of KYNA in DLPFC [141] and may enhance mGluR3 signalling [219], which ameliorates DLPFC network connectivity and DLPFC neuronal firing [28]

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