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Clin J Am Soc Nephrol 4: 470480, 2009 [DOI] [PubMed] [Google Scholar] 104.Krieger CC, An X, Tang H-Y, Mohandas N, Speicher DW, and Discher DE

doi: 10.1073/pnas.1000087107

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93,94 In humans, vitamin C has been shown in multiple randomized, double-blind, placebo-controlled trials to help with both depression and anxiety in patients of various ages as well as with opioid addiction

Its relatively larger size and surface area make it susceptible to phagocytic clearance, making it impossible to reach the target