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The remarkable aspects of this case are its rather impressive clinical presentation and its occurrence in a male patient, which have rarely been described

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Knockdown of NNMT in adipocytes was associated with increased NAD+ levels and altered expression of genes involved in energy expenditure, providing the rationale for pharmacological NNMT inhibition [2]

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Pregnant or breastfeeding women who suspect B12 deficiency should have their levels tested by their prenatal care provider, who can recommend the appropriate supplementation route and dosage