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Eur J Pharmacol 570:212221 Malavaud B, Tack I, Jonca F, Praddaude F, Moro F, Ader JL, Plouet J (1997) Activation of Flk-1/KDR mediates angiogenesis but not hypotension

Zinc depletion with prolonged supplementation 2

This is a significant advantage, especially for individuals with malabsorption issues stemming from conditions like Crohn's disease, celiac disease, irritable bowel syndrome (IBS), or post-bariatric surgery complications, where oral supplementation may be ineffective due to impaired absorption

It may, however, increase the likelihood of side effects

Randomized trial of longer-term therapy for symptoms attributed to Lyme disease