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When it complicates another condition (e.g., heart failure with cardiac cachexia), sequence the primary condition first and malnutrition/cachexia as secondary

Subsequent MRI spectroscopy work by the same group documented favorable shifts in brain metabolite ratios

Conventional medical practitioners are more cautious because not all effects have been clearly proven yet

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The phosphoinositide 3-kinase (PI3K), Akt, and mammalian target of rapamycin (mTOR) signaling pathways have been identified as significant players in mediating the effects of OS in the nervous system (Maiese et al., 2012)