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(2013), p -coumaric acid has a protective effect similar to the standard antioxidant vitamin C on the rat heart damage caused by the pretreatment of sodium arsenite (5 mg/kg bm, 30 days) with respect to oxidative stress and cardiac tissue markers due to its antioxidant properties

Targeting Notch degradation system provides promise for breast cancer therapeutics

These findings suggest that pathological cardiac pressure overload induces NNT reverse functional mode to generate NADH at the expense of NADPH resulting in a high NADH/NAD + and reductive stress, further promoting ROS at complex I leading to oxidative injury and cell death (Fig

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In a more recent model, proximal tubule-specific deletion of MnSOD in diabetic mice produced stage-dependent effects: early diabetes was associated with improved kidney function via NRF2 activation and enhanced fatty acid oxidation, while late-stage disease showed worsened renal injury due to impaired mitochondrial respiration and heightened inflammation, highlighting MnSODs dual role in disease progression [59]