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On the downside, high intensity activity causes an increase of free radical production within the body and can temporarily weaken the immune system

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Breaks maintain receptor sensitivity and allow copper levels to normalize

Mol Cell Biol 33: 242535

The curcumin and gallic acid -loaded microneedles provide immediate antioxidant and anti-inflammatory effects, alleviating AD symptoms in the short term, while the embedded PLGA needle mediates the sustained release of curcumin for long-term improvement
