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For these initial efficacy studies, we elected to test drugs with one dose of ionizing radiation rather than conducting fractionated radiation doses to minimize tissue damage and animal stress

By analysing epigenetic silencing modifications (H3K27me3), Dror et al [46] identified two beta cell subtypes (beta-high and beta-low), matching clusters previously identified in mice and humans, including beta1/beta2 from Dorrell et al [47] and INS high/low from Chiou et al [48]
