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2.6 Innate T cells Innate T cells, including gamma delta () T cells, mucosal-associated invariant T (MAIT) cells, and natural killer T (NKT) cells, recognize antigens in a manner unrestricted by classical major histocompatibility complex (MHC) class I or II and respond rapidly upon activation (78)

Inflammation, oxidative stress, Ca 2+ dysregulation, and hypoxia can induce cellular endoplasmic reticulum stress (ERS) by overloading the ERs protein folding mechanism ( Some studies have found that ferroptosis and ERS share a common pathway, especially in tumor diseases, and disease trends can be altered by controlling the ERS or ferroptosis pathway ( 2 Ferroptosis in RA With the study of RA disease mechanisms, it has been found that the aberrant activation of RA-FLSs, destruction of articular cartilage, overactivation of immune cells, and sustained expression of inflammatory factors are associated with ferroptosis