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However, during clinical translation, the structural complexity of the human liver, the heterogeneity of disease microenvironments, and interspecies differences often lead to suboptimal performance of nanodrugs in human trials despite promising results in preclinical animal studies

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Appl Biochem Biotechnol 168:198205 Wang C, Zhang J, Wu H, Li Z, Ye Q (2015) Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production

Most cases resolve within a few days, but in more severe instances, symptoms can linger or cause dangerous dehydration