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Schizophr Res 120 : 131142

Further experiments confirmed that NAC mainly increased the expression of GPX4 by upregulating sirtuin-3 (SIRT3) and inhibiting the acetylation of superoxide dismutase 2 (SOD2), thereby inhibiting cell ferroptosis and improving kidney function in DKD[149]

A daily intake of 90 mg for men and 75 mg for women is recommended, with an additional 35 mg intake recommended for smokers ( Vitamin C deficiency is rare in developed countries