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Possible Mechanisms Underlying Fatigue-Ameliorating Effects H 2 has been reported to exert anti-fatigue effects in experimental animals and healthy subjects by increasing exercise capacity (46, 5053, 5557), reducing fatigue indices (51, 56), and inhibiting increases in blood lactate levels due to muscle fatigue (46, 50, 52)

While multi-omics studies link microbial signatures, BA profiles, and cancer outcomes (Section 4.3), their precise mechanistic underpinnings are often elusive, a recognized issue in complex diseases (163, 187, 188)

51 In vivo comparison of the anti-EphA2 3F2 antibody conjugated to MMAE with the vc linker and the anti-EphA2 3F2 antibody conjugated to MMAF with the mc linker as compared to control R347 conjugated to MMAE or MMAF, and PBS in the PC-3 human prostate cancer cell line