glutathione tumor suppressor Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung cancer by reprograming the microenvironment Cysteine metabolic circuitries: druggable targets
Description
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10.1021/acscentsci.6b00199 141 KrylovaI
RNA-Seq data and CUT&RUN data generated in this study were uploaded into the National Center for Biotechnology Information Gene Expression Omnibus database (GSE236742, GSE270779)
Glutathione does not survive digestion well on its own
its cytoplasmic domain functions as an aminoacyl-PG synthase that uses PG and aminoacyl-tRNA as substrates, whereas its membrane-embedded domain acts as a flippase that translocates aminoacyl-PG to the outer leaflet of the membrane 14
