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Both NAPQI and ROS cause mitochondrial DNA damage, activation of the JNK signaling pathway, which further amplifies the mitochondrial ROS production, and causes the mitochondrial permeability transition (MPT) pore to open (Iorga et al., 2017)

Fish Oil Some studies have found that supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from fish oil may reduce kidney stone risk by lowering urine calcium

Taketa T, Correa AM, Suzuki A, Blum MA, Lee JE, Welsh J, Lin SH, Maru D, Erasmus JJ, Bhutani MS, Weston B, Rice DC, Swisher S , Hofstetter WL, Ajani JA

Over time, spinal ligaments can thicken and further reduce space within the spinal canal

not cherry-picked data from small trials & anecdotal feedback 5