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Recent evidence suggests that in ovarian cancer, NNMT expression is associated positively with PGAM1, which is involved in the Warburg effect, enabling the elucidation of the resistance mechanism of bevacizumab
Conway MC, Yeates AJ, Love TM, Weller D, McSorley EM, Mulhern MS, Wesolowska M, Watson GE, Myers GJ, Shamlaye CF, Henderson J, Davidson PW, van Wijngaarden E, Strain JJ The British journal of nutrition
The preference between these two pathways is contingent on the extracellular concentration of glutamate (Anderson and Swanson, 2000)
Johnson CE, Vigoreaux JA
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