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Since singlet oxygen and lipids are substrates of lipid peroxide, removing singlet oxygen can prevent lipid peroxidation [139,140,141,142,143]

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In a murine model of renal cell carcinoma, upregulation of G6PD and subsequent increase in NADPH was found to inhibit ferroptosis whereas G6PD knockdown in human hepatocellular carcinoma cells increased positive regulators of ferroptosis 83,84,85

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