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This conversion results in increased fibroblast-like activity, excessive extracellular matrix deposition, and myocardial fibrosis, ultimately impairing cardiac function [12]

PFKFB3, a significant regulator of glycolysis that is often upregulated in cancers, has inhibitors (e.g., PFK15 and PFK158) that have displayed anti-neoplastic properties in preclinical studies [143]

3.2.1.2 Solid lipid nanoparticles Solid lipid nanoparticles (SLN) are discs or elliptical spherical particles composed of solid lipids, water, and surfactants at room temperature, and the drug may be attached to the surface of the carrier or encapsulated in a core (Scioli Montoto et al., 2020)

Analyses included the effects of various dosing conditions (such as fasting time and water volume), demographic covariates and variability in exposure following single and multiple oral administration

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