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Description
In patient-derived glioblastoma models, GPX4 inhibition leads to a rapid and selective induction of ferroptosis in CD133 + GSCs, whereas differentiated non-GSCs remain comparatively resistant [149]
In other NDDs like HD, activated microglia and reactive astrocytes worsen the HD condition by boosting pro-inflammatory genes, leading to persistent inflammation 133 (Fig
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Ligand immobilization was carried out in flow cell 2 with a series of ligand injections at a flow rate of 5 l min 1 until the desired density was achieved (700 RU for ENL_YEATS ternary complex, 1,800 RU for ENL_YEATS small-molecule binding and 4,430 RU for CRBN midi )
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