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doi: 10.1016/j.jneuroim.2010.10.025

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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing

Thus, we used the 7 nAChR blocker MLA to confirm its function on pain and found that MLA reversed the analgesic effect of nicotine

Orient the transducer in the direction of the piriformis muscle and move caudally until the sciatic notch is identified