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However, in HCC, its sustained activation acts as a double-edged sword: rather than acting solely as a cytoprotective factor, NRF2 facilitates tumor survival, proliferation, and resistance to treatment by preventing ferroptotic cell death and enabling metabolic reorganization [49, 50]
Devasagayam TP, Kamat JP, Mohan H, Kesavan PC (1996) Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species
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Meredith JD, Chapman I, Ulrich K, Sebastian C, Stull F, Gray MJ
