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Description
798 On the other hand, using synthetic approaches allows nonproteinogenic amino acids to be readily introduced into the core peptide
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S1P is formed in two steps from ceramide by ceramidase converting it to sphingosine, which is then phosphorylated to S1P by sphingosine kinase 1 and 2 (SK1 and SK2)
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The enzyme-inhibitor complexes show that the binding of ligand into the electrophilic binding site does not lead to any conformational changes of the protein
